D)
Because a hypothesis is an "Educated Guess" so it obviously cannot be a principal that is used in Science. For Example, I could say my hypothesis on Men and Women is that Women are smarter. This is not necessarily true because I don't have any facts yet. In order to discover the answer, I must A) Attempt to answer and see if this is true, B) Evaluate this by doing experiments, and C) I must change my hypothesis so it is correct. I cannot say this is a "Universal Principle" by stating it.
Hope I helped :-)
