Sagot :
In this group of people with post-stroke spasticity in three 12- to 42-week clinical trials who had >/=1 therapy with a particular BoNTA formulation at doses spanning from 100 to 400 U, the formation of NAbs was uncommon (1/191).
What is Spasticity?
Spasticity is a characteristic of altered skeletal muscle function along with paralyzing, enhanced tendons reflex activity, and increased tone. Its name comes from the Greek word spasms, which means "drawing, pulling." It is also known as an unusual "tightness," "stiffness," or "pull" of muscles in everyday speech.
Clinically speaking, spasticity is the result of excessive velocity-dependent muscular contraction brought on by the motor neurons' loss of inhibition. In the end, this results in hyperreflexia, which is an accentuated deep tendon reflex. The medication baclofen, which works as an agonists at inhibitory GABA receptors, is frequently used to treat spasticity.
The most prevalent type of cerebral palsy, that is a collection of persistent movement issues that do not become worse with time, is spastic cerebral palsy. Baclofen's effectiveness as an anti-spasticity medication is influenced by the inhibiting effects of GABA.
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