There exist a link between lung fibrosis and stress on the endoplasmic reticulum.
Many fibrotic diseases such as Idiopathic Progression Fibrosis are related to the stress on the endoplasmic reticulum. The discovery of the first case of ER stress was fifteen years ago along with the discovery of a mutation in protein C. With apoptosis of alveolar epithelial cells, differentiation of fibroblast and polarization M2 macrophage, lung fibrosis, and ER stress is linked with each other.
Various analyses and tests are being performed to understand the effects of ER stress and the factors that result in ER result in cells such as macrophages, alveolar epithelial cells, and fibroblasts. So, there exists a link between lung fibrosis and stress on the endoplasmic reticulum.
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