Implications for clinical LSD use: Cytochrome P450 enzymes participate in the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD. This cell-based (in vitro) study examined the possibility for clinical LSD usage and the role of the cytochrome P450 (CYPs) enzymes in the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD.
This cell-based (in vitro) study examined the possibility for clinical LSD usage and the role of the cytochrome P450 (CYPs) enzymes in the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD. The study discovered that multiple CYPs significantly contributed to the process even though the human liver only converted a little amount of LSD to nor-LSD and O-H-LSD.
According to the metabolism, there is a connection between genetic polymorphisms and pharmacological interactions, which may have an impact on the pharmacodynamics and pharmacokinetics of LSD. Additionally, it was discovered that O-H-LSD is inactive whereas nor-LSD may have inactive hallucinogenic effects similar to that of LSD.
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