The genus _______ is an extremely important member of the apicomplexan group because several of its species are the causative agents of malaria.

Sagot :

The genus plasmodium is an extremely important member of the apicomplexan group because several of its species are the causative agents of malaria.

Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of Plasmodium species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue (often the liver) before entering the bloodstream to infect red blood cells. The ensuing destruction of host red blood cells can result in malaria. During this infection, some parasites are picked up by a blood-feeding insect (mosquitoes in majority cases), continuing the life cycle.

The life cycle of Plasmodium involves several distinct stages in the insect and vertebrate hosts. Parasites are generally introduced into a vertebrate host by the bite of an insect host (generally a mosquito, with the exception of some Plasmodium species of reptiles). Parasites first infect the liver or other tissue, where they undergo a single large round of replication before exiting the host cell to infect erythrocytes.

At this point, some species of Plasmodium of primates can form a long-lived dormant stage called a hypnozoite. It can remain in the liver for more than a year. However, for most Plasmodium species, the parasites in infected liver cells are only what are called merozoites. After emerging from the liver, they enter red blood cells. They then go through continuous cycles of erythrocyte infection, while a small percentage of parasites differentiate into a sexual stage called a gametocyte which is picked up by an insect host taking a blood meal.

In some hosts, invasion of erythrocytes by Plasmodium species can result in disease, called malaria. This can sometimes be severe, rapidly followed by death of the host (e.g. P. falciparum in humans). In other hosts, Plasmodium infection can apparently be asymptomatic.

Even when humans have such subclinical plasmodial infections, there can nevertheless be very large numbers of multiplying parasites concealed in, particularly, the spleen and bone marrow. These hidden parasites (in addition to hypnozoites) are thought to be the origin of instances of recurrent P. vivax malaria.

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