What is the best definition of addiction? Question 1 options: Addiction is a condition in which a person has an intense craving for a substance that is difficult to resist. Addiction is a social problem in which a person suffers negative effects in his or her life from taking a substance. Addiction is when a person takes so much of a substance that serious effects occur requiring hospitalization. Addiction is a chronic problem in which a person has altered his or her brain and can't stop taking a substance.