I believe the answer is:The colonists killed a Powhatan leader and the Powhatan's attacked back.
But in settlers community, they framed it as if the native indians were somehow crude and agressive toward their millitary personels. This led to the millitary action made by the settlers which later known as the Indian Massacre of 1622 that occured in Virginia colony.
Answer:In 1622 colonists killed a Powhatan leader, the Powhatan responded by attacking the Virginia settlers later that year, fighting between the colonists and the Powhatan continued for the next 20 years.
